High-quality raw materials and excipients, filled and selected as required? Why not!

Excipients

Carefully selected additives for your special requirements? Why not! Choosing the right raw material or excipient is one of the first and most important steps in a long manufacturing process. BIOGRUND supports you right from the start and helps you to maximize the chances of perfect formulation of solid oral dosage forms.

Are you in the development phase? Or do you only need a small amount of raw materials / excipients for some of your products? We are just as specialized in these requirements as we are in larger quantities.

High-quality raw materials for your product:

  • Film formers (e.g. Hydoxypropylmethyl Cellulose | HPMC | Hypromellose)
  • Binder (e.g. NaCMC)
  • Tableting excipients (e.g. NaCMC | HPC | PVP)
  • Thickener (e.g. NaCMC | HPMC)
  • Plasticizer (e.g. glycerol)
  • Polishing agent (e.g. for tablets / sugar dragées, for excellent shine)
  • Anti-sticking (e.g. for soft gelatine capsules)
  • Pigments (natural, synthetic, iron oxides)
Excipients Biogrund

Cellulose Ethers (HPMC, MC, EC, HEC, NaCMC)

BonuCel® H – the flexible polymer for your formulation needs

In the field of hypromellose (HPMC), our BonuCel® H offers a wide range of standard viscosities for different application requirements. When adjusting the viscosity, we adapt to your needs. BonuCel® H is manufactured to IPEC GMP guidelines and meets all the requirements of USP/NF, Ph.Eur. and JP. The registration number is CAS 9004-65-3. The material is provided by BIOGRUND GmbH, Germany.

The versatile BonuCel® is also available as methylcellulose (MC), ethylcellulose (EC), hydroxyethyl cellulose (HEC) and sodium carboxymethyl cellulose (NaCMC).

Tylopur Xtend Nutra® - Cellulose for extended release

TYLOPUR XTEND NUTRA® enables a sustainied/delayed release of the active ingredient. It is suitable for use in tablet formulations for direct compression.

TYLOPUR XTEND NUTRA® is a plant derived cellulose-based ingredient. It has been specially developed for nutraceutical and dietary supplement applications.

Benefits:
– Your active ingredient gains a extended/delayed release profile … naturally.
– Your capsule formulation is optimized into a tablet.
– Get the optimum dosage and smallest possible tablet size.
– Your costs can be reduced: The production of tablets is more cost-effective compared to capsules.

TYLOPUR XTEND NUTRA® is a plant derived product that complies to European and US-American guidelines and guarantees the exclusion of non-conformig ingredients (dioxides, stearates). Manufacturer: ShinEtsu (SE Tylose Gmbh & Co. KG / SE Tylose USA, Inc.)

BIOGRUND is one of the official distributors.

Link: More product information (specifications, brochure, sample request)

Tylopur® DG - 4T - Polymer for hand sanitizer gel

Polymer for the preparation of hand sanitizer gel – A special Hypromellose type

Hand sanitizer gel is a hydroalcoholic gel formulated with a high level of alcohol. The Center for disease control and prevention (CDC) recommends a minimum of 60 percent alcohol for an alcohol-based hand sanitizer. [1]

Hypromellose (HPMC) has a good solubility in alcohol. The formulation of hand sanitizer gels use polymers as thickener agents to increase the viscosity of the gel. Shin-Etsu HPMC TYLOPUR® DG-4T (Hypromellose 2910) is a suitable thickener for this application due to the stability in and compatibility with organic solvents.

Beside the thickener agent (e.g. HPMC), a humectant (e.g. glycerine, propylene glycol) is needed in the formulation. Additionally, a chelating agent can be used, such as tetra sodium EDTA or sodium citrate. Fragrances and extracts can also be added to the gel. A neutralizing agent, such as sodium hydroxide, can be used to achieve the desired pH.

Link: More product information (specifications, brochure, sample request)Link: More product information (specifications, brochure, sample request)

Hot Melt Coating, Polishing & Waxing

BonuWax®

Easy-to-use application for hot melt coating of particles, polishing of sugar-coated tablets and anti-sticking of soft capsules.

Our ready-to-use excipient premix BonuWax® for hot melt coating is a water and solvent free application and provides good moisture sealing, taste masking and stability for granules and particles.

If a shiny surface is requested for sugar-coated tablets, BonuWax® as a mixture of bee wax and carnauba wax can be used to achieve an excellent glossy finishing. Under the principle of friction, a brilliant gloss/shine will be realized, which leads to an aesthetic valorization for sugar-coated tablets.

BonuWax® is formulated with different natural waxes and is highly stable to provide excellent transparency, anti-sticking properties (effective separation) and enhanced mechanical stability/flowability during processing and packaging. Waxed capsules also have higher resistance to external influences like humidity and temperature and are easier to swallow.

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Hot Melt Extrusion Cleaner

HME Cleaner Plus (GMP)

A purge compound for hot melt extrusion terminates difficulties to clean the extruder after processing.

HME Cleaner Plus (GMP) is an almost water-soluble purge compound with a micro-cleansing effect which solves this cleaning difficulty for the HME process. HME Cleaner Plus (GMP) provides effective clean-up because of its high detergency and low residual properties.

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