CBD / HEMP.
What is CBD? 1-4
CBD stands for cannabidiol. It is the second most common active ingredient in cannabis (marijuana) and one of the 113 cannabinoids found in the hemp plant. Full-spectrum hemp products contain all of these substances, including traces of THC. To obtain CBD without THC, it must be isolated. By isolating the CBD, all other compounds are removed.
Clinical research studies on the effects of CBD have been collected for several years. However, there are currently insufficient, high-quality results on whether CBD is effective for conditions such as anxiety, cognition, movement disorders and pain.
How can CBD be taken?
There are several ways in which CBD can be absorbed:
- Inhalation of cannabis smoke or vapour
- Aerosol spray
- Oil
- Oral drops/tinctures, to drop under the tongue
- Capsules (filled with liquid)
- Edibles such as gummy bears
POSTER
From oil to powder to capsule – The natural way
Introduction:
The industry is endeavouring to supplement its natural supplements with vitamins, probiotics, omega-3-6-9 fatty acids, antioxidants, amino acids and hemp. Often in the form of an oil or oily powder. With the latter, manufacturers can achieve some benefits by using microencapsulation for oil powder. Especially if the oil powder is then filled into hard gelatine capsules, an exact dosage of the ingredients or nutrients can be achieved. By masking taste and odour, unpleasant tastes and odours associated with certain nutrients can be minimised. Protection against moisture, acids, heat and oxygen. It improves stability, bioavailability and delivery. It is also easier to handle as it is dry and free-flowing.
What is the industry looking for?
- Simplification of intake, handling and precise dosing
- Taste and odour masking
- New dosage forms. Drops are already available on the market, capsules and tablets could expand the portfolio.
- Savings in production costs. Liquid-filled capsules are relatively expensive.
- Therefore, it could be a good option to convert the oil into powder to prepare it for tablets and hard capsule production.
- Optimising the bioavailability
- clean-label products in the nutraceutical and food industry.
Natural food supplements with CBD, natural vitamins, probiotics, omega-3-6-9 fatty acids and antioxidants
The industry is endeavouring to add natural sources of vitamins, probiotics, omega-3-6-9 fatty acids, antioxidants, amino acids and hemp to its natural food supplements. Often in the form of an oil or an oily powder. Speaking of the latter: manufacturers can achieve a number of benefits by microencapsulating oil powders. Especially when the oil powder is then filled into hard gelatine or hypromellose capsules, a precise dosage of ingredients or nutrients can be achieved. Taste and odour masking can minimise unpleasant tastes and odours associated with certain nutrients. Protection from moisture, acids, heat and oxygen. It improves stability, bioavailability and delivery as well as handling through dry and free-flowing powder.
The incorporation of oily substances into powders with purely natural ingredients and the encapsulation of the product or the compression of a tablet can thus be carried out easily. And it could also open up the possibility of combining CBD with other active ingredients. For example, natural active ingredient powder premixes such as CompactCel® MAB can support the absorption of oily substances such as hemp in a ratio of up to 1:8.
Example:
20 mg of hemp should be filled into a size 0 capsule. This means that approx. 30 mg of oil (with 20 mg CBD) must be incorporated into 500 mg of powder. Consequently, 6 % of the oil must be in the capsule. By using CompactCel® MAB for oil absorption, it is possible to bind up to 12.5 % oil in the powder. And even after that, it still has good flow properties. This makes it easy to fill hard capsules without the powder mass clumping together.
Request your free CompactCel® MAB sample:
IMPORTANT:
Regarding the exact legal status of CBD please inform yourself about federal government laws of your country.
References:
1-3 https://en.wikipedia.org/wiki/Cannabidiol
– Campos AC, Moreira FA, Gomes FV, Del Bel EA, Guimarães FS (December 2012). “Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders”. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences (Review). 367 (1607): 3364–78. doi:10.1098/rstb.2011.0389. PMC 3481531. PMID 23108553.
– Black N, Stockings E, Campbell G, Tran LT, Zagic D, Hall WD, et al. (December 2019). “Cannabinoids for the treatment of mental disorders and symptoms of mental disorders: a systematic review and meta-analysis”. The Lancet. Psychiatry. 6 (12): 995–1010. doi:10.1016/S2215-0366(19)30401-8. PMC 6949116. PMID 31672337.
– VanDolah HJ, Bauer BA, Mauck KF (September 2019). “Clinicians’ Guide to Cannabidiol and Hemp Oils”. Mayo Clinic Proceedings. 94 (9): 1840–1851. doi:10.1016/j.mayocp.2019.01.003. PMID 31447137.
4 https://www.health.harvard.edu/blog/cannabidiol-cbd-what-we-know-and-what-we-dont-2018082414476