Advantages of HMC
One advantage for the pharmaceutical industry is the simplification of complex dosage schemes, as several active ingredients can be combined, even those that cannot normally be combined. As the frequency of administration and complexity for users is reduced, the user-friendliness for patients is significantly improved.
The coating ensures that the active ingredients are protected against chemical degradation and their stability is increased until they are taken. The HMC process can be used flexibly. Direct granulates, hard and soft gelatine capsules or MUPS (Multiple Unit Pellet System) tablets can be coated with the process.
A further advantage is the masking of bitter active ingredients, such as caffeine tablets, and the possibility of a controllable release of active ingredients. There are different ways to coat particles.
By using an HMC the coating process can be significantly shortened.
A comparison of the HMC with a polymer coating can confirm this. The HMC process takes 42 minutes and is therefore almost seven times faster than the process with the polymer solution, which takes 278 minutes. In both processes the weight of the active ingredient is 1000 g, the spray rate is 12 g/min and the use of wax or polymer, 500 g.
Because the wax is a melt, there is no suspension. The polymer, on the other hand, must be dissolved in water or in an organic solvent. In this example the amount of water is 2833 g. This means that more product is needed to coat the active ingredient.