CompactCel® TC

Neutralising agent for bad tasting
actives? Why not!

BIOGRUND’s tabletting agent CompactCel® TC provides an easy to use and homogeneous compound of several sugar alcohols and cellulose fibers, which acts as a perfect taste masking dry binder.

Active pharmaceutical ingredients (API) with an unpleasant taste are not easy to handle, when they are processed in uncoated solid oral dosage forms. The challenge is to achieve a pleasantly tasting tablet in a simple way. Therefore adding specific ingredients to the tablet mass can be an effective solution to cover poor taste.

CompactCel® TC with its various components can be customized formulated with different excipients like cellulose fibers, sugar substitutes (e.g. Sorbitol, Maltitol, Isomalt), beta-cyclodextrin or sodium carboxymethylcellulose. Depending on customer requirements, components can be modified, added or reduced.

These components are selected due to their positive characteristics.  Betacyclodextrin features the building of complexes with the API so that poor
taste can be covered. By building a gel, sodium carboxymethylcellulose masks the natural flavour of the active substance. Cellulose fibers, however, having the character to coat the whole tablet mass and with the use of sweeteners, undesired tastes in the formulation can be concealed.

To achieve best taste covering results BIOGRUND recommends adding 5–10% CompactCel® TC to the tablet mass before the compaction process. The product can be used for pharmaceutical and nutritional applications.

Regulatory and quality aspects:
All CompactCel® TC formulations are developed to comply with official regulatory requirements of the user’s country for pharmaceutical products and for nutritional or dietary supplements.